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Ranitidine
Uses
Ranitidine blocks the action of histamine on stomach cells,
and reduces stomach acid production. Ranitidine is useful in
promoting healing of stomach and duodenal ulcers, and in
reducing ulcer pain. Ranitidine has been effective in
preventing ulcer recurrence when given in low doses for
prolonged periods of time. In doses higher than that used in
ulcer treatment, ranitidine has been helpful in treating
heartburn and in healing ulcer and inflammation of the
esophagus resulting from acid reflux (reflux esophagitis).
Ranitidine is a
histamine H2-receptor antagonist that
competitively inhibits the action of histamine on the H2-receptors
of the parietal cells. As a result, ranitidine reduces the
volume of acid and pepsin secreted under basal conditions,
and in response to a variety of stimuli, such as food and
pentagastrin. Ranitidine has little or no anti-androgenic
effect. A single 150mg dose of ranitidine suppresses acid
secretion for 12 hours due to its long action duration.
Ranitidine
Indications
Ranitidine is
indicated in the treatment of duodenal ulcers and benign
gastric ulcers. The pathogenesis of duodenal ulcer includes
a number of factors with infection with H. Pylori being a
major factor. Eradication of H. Pylori reduces the relapse
rate for duodenal ulcers. A treatment regimen comprising
ranitidine, amoxycillin and metronidazole is effective for
the eradication of H. Pylori and for the treatment of
duodenal ulcers associated with this organism.
Ranitidine is
also indicated for the treatment and prevention of duodenal
ulcers and benign gastric ulcers associated with
nonsteroidal anti-inflammatory agents.
Ranitidine is
also indicated for reflux oesophagitis with or without
oesophageal erosions, chronic non-ulcer dyspepsia,
Zollinger-Ellison syndrome and other gastric hypersecretory
states.
Ranitidine may
be used at reduced dosage, as maintenance therapy in
patients with a history of recurrence or complication of
duodenal or benign gastric ulcer, or in patients for whom
surgery would be contra-indicated.
Ranitidine may
be used prophylactically to prevent ulceration in patients
who are on long-term NSAID therapy and who have a previous
history of ulceration. It may also be used prophylactically
to prevent haemorrhage from stress ulceration in seriously
ill patients, and recurrent haemorrhage in patients with
bleeding peptic ulcers. It may also be used before general
anaesthesia in patients at high risk of acid aspiration or
by obstetric patients during labour.
Ranitidine
Directions
Follow the directions for using this medicine provided by
your doctor. Completely dissolve this medicine in 6 to 8
ounces of water, then drink. ANTACIDS MAY BE USED with this
medicine unless directed otherwise by your doctor. STORE
THIS MEDICINE at room temperature, away from heat and light.
IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as
possible. If it is almost time for your next dose, skip the
missed dose and go back to your regular dosing schedule. Do
not take 2 doses at once.
Ranitidine Cautions
IF YOUR SYMPTOMS DO NOT IMPROVE or if they become worse,
check with your doctor. CONTINUE TAKING THIS MEDICINE for
the full course of treatment even if you feel better. DO NOT
DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE
DANGEROUS until you know how you react to this medicine.
Using this medicine alone, with other medicines, or with
alcohol, may lessen your ability to drive or to perform
other potentially dangerous tasks. PHENYLKETONURICS: This
medicine contains phenylalanine. Check with your doctor
before taking this medicine. FOR WOMEN: THIS MEDICINE IS
EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking
this medicine.
Ranitidine is
renally excreted and caution is required in patients with
impaired kidney function due to the potential for increased
plasma levels.(see Dosage and Administration).
Ranitidine may
mask the symptoms of carcinoma of the stomach thus delaying
correct diagnosis. This possibility should be excluded
before starting therapy especially in patients with gastric
ulcer or in middle-aged or older patients with new or
changed dyspeptic symptoms.
Regular
supervision is recommended for patients taking NSAID
concomitantly with ranitidine.
Ranitidine may
precipitate acute porphyric attacks and its use should
therefore be avoided in patients with a history of acute
porphyria.
Ranitidine Drug interactions
Drug interactions can result in unwanted side effects or
prevent a medicine from doing its job. Use our drug
interaction checker to find out if your medicines interact
with each other. Check drug interactions
Ranitidine Notes
DO NOT SHARE
THIS MEDICINE with others for whom it was not prescribed. DO
NOT USE THIS MEDICINE for other health conditions. KEEP THIS
MEDICINE out of the reach of children. IF USING THIS
MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills
before your supply runs out
Ranitidine Side
Effects
Ranitidine is
well tolerated, and any adverse effects are generally of
mild to moderate severity and appear to be reversible on
reduction of dose or stopping therapy.A SIDE EFFECT, that
may go away during treatment, is headache. If it continues,
or is bothersome, check with your doctor. If you notice
other effects not listed above, contact your doctor, nurse,
or pharmacist.
Ranitidine
Overdose
Ranitidine
appears to be well tolerated even after large doses.
However, in the event of overdose symptomatic and supportive
therapy should be instituted as appropriate. If considered
necessary, ranitidine may be removed from the plasma by
haemodialysis.If overdose is suspected, contact your local
poison control center or emergency room immediately.
Symptoms of overdose may include difficulty breathing, fast
heartbeat, tremors, vomiting, and restlessness.
Ranitidine Overdose
Store below
30°C. Protect from heat, light and moisture. Keep containers
tightly closed.
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